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January 1973

Immunosuppression in Arterial and Venous Allografts

Arch Surg. 1973;106(1):75-78. doi:10.1001/archsurg.1973.01350130077017

Segments of arteries and veins were interposed in canine carotid arteries as isografts and allografts. The dogs were given azathioprine and prednisone for immunosuppression. In this study immunosuppressive drugs did not significantly alter the gradual deterioration and necrosis of allograft arteries and veins. The allograft vessels failed due to rejection-induced thrombosis that was not altered by immunosuppression.