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January 1973

Infusion of Cell-Free Fluids Into Rabbits in Hemorrhagic Shock: Replacement of Blood With Crystalloid Fluids of Various Tonicities

Arch Surg. 1973;106(1):86-89. doi:10.1001/archsurg.1973.01350130084019

Acellular nononcotic solutions of various osmolalities and compositions were tested for their life-sustaining abilities in acute hemorrhagic shock in rabbits where blood was replaced on a volume-for-volume basis. Osmolal and hyperosmolal solutions were more effective in sustaining life than conventionally used lactated Ringer's solution or hypoosmolal solutions. Survival rate of experimental animals was further improved and approached that obtained with reinfusion of autologous blood by the use of synthetic tissue culture type hyperosmolal solutions.