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March 1973

Chronic Intravascular Coagulation in Metastatic Prostate Cancer

Author Affiliations

Columbia, Mo
From the Section of Urology, Department of Surgery (Drs. Bruns and Ross), and Section of Hematology and Oncology, Department of Medicine (Dr. Samaha), University of Missouri Medical Center, Columbia.

Arch Surg. 1973;106(3):295-298. doi:10.1001/archsurg.1973.01350150035010

A mild bleeding tendency and obstructive urinary tract symptoms of several weeks' duration occurred in two patients. Both were found to have mild to moderate thrombocytopenia and metastatic prostate cancer involving the bone marrow. During hospitalization, both developed gross bleeding requiring transfusion therapy. Results of routine clotting studies were normal but additional tests, consisting principally of a positive test for fibrin monomers and a normal euglobulin lysis time, revealed the presence of chronic disseminated intravascular coagulation. Heparin sodium therapy was successful in stopping the bleeding in both patients. Cryofibrinogen was found in abnormal amounts before and after heparin therapy.

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