A patient developed osteomyelitis of the clavicle after an indwelling catheter had been used in the subclavian vein for eight days. The catheter had been employed to administer ampicillin sodium and methicillin sodium to treat postoperative staphylococcal bacteremia and wound infection following repair of a hiatus hernia. Subperiosteal claviculectomy and methicillin produced a cure.