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To the Editor.—Dr. Grogan has pointed out in his letter our admonition that hyperalimentation solutions must not be given through a catheter into a peripheral vein because in our experience infection and chemical phlebitis will occur more frequently. We also said that we have not found it necessary to use a polymer filter with these solutions. He points out that hyperalimentation solutions have been given by way of peripheral veins in infants and that catheter problems do not occur during approximately two days and in another study in less than 36 hours. Our patients were all adult, general-hospital patients who required prolonged periods of hyperalimentation. We do not feel that hyperalimentation serves any purpose if given for only several days and, therefore, for prolonged use a catheter in the central circulation is mandatory. In-line filters have been found to be helpful by some, but we did not find them