Clindamycin phosphate, a parenteral preparation of the antibiotic clindamycin, was used to treat 131 patients with documented bacterial infections. Clindamycin therapy effectively eradicated 81% of the infections. There were no apparent systemic toxic effects. Injections of clindamycin phosphate were satisfactorily tolerated for as long as three weeks. Resistant Staphylococcus aureus developed in 8% of the cases.
Thus, parenterally administered clindamycin phosphate appears to be safe and effective in treating serious surgical infections due to gram-positive organisms and shows promise in treating anaerobic infections.
Schumer W, Nichols RL, Miller B, Samet ET, McDonald GO. Clindamycin in the Treatment of Soft-Tissue Infections. Arch Surg. 1973;106(4):578–581. doi:10.1001/archsurg.1973.01350160190033
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