Wedge-shaped fractures of the tibiae of rats and dogs were locally treated with soluble collagen of pigskin. As a result of this, significantly higher stability levels of the fracture callus were achieved in a shorter time than in controls. Earlier formation of the callus was proved histologically. The serum determinations indicated a mineral deposit on the protein matrix that occurred much sooner than in the control fractures.
Benfer J, Struck H. Experimental Studies on Fracture Healing: III. Accelenrated Fracture Healing Through Soluble Heterologous Collagen. Arch Surg. 1973;106(6):838–842. doi:10.1001/archsurg.1973.01350180072021
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