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August 1973

Metabolic and Microcirculatory Effects of Glucagon in Hypovolemic Shock

Author Affiliations

From the Department of Surgery, University of Illinois College of Medicine, Abraham Lincoln School of Medicine; and the West Side Veterans Administration Hospital, Chicago.

Arch Surg. 1973;107(2):176-180. doi:10.1001/archsurg.1973.01350200050013

Glucagon infused into Macaca rhesus monkeys in hypovolemic shock significantly improved splanchnic microcirculatory perfusion, increased pH, and decreased phosphate, lactate, amino acid, and fatty acid levels as compared to the controls. Further, in vitro rat liver perfusion studies showed that glucagon significantly increased lactic acid extraction, even after reducing oxygen pressure and perfusant flow to a minimum. Thus, in addition to its cardiotonic and vasodilatory effects, glucagon was shown in this study to improve perfusion in the splanchnic microcirculation and to decrease anaerobic metabolites. These findings support its use in the treatment of hypovolemic shock.

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