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January 1974

Intrinsic Plasma Volume Deficits in Patients With Coronary Artery Disease: Effects of Myocardial Revascularization

Author Affiliations

From the Department of Surgery, Division of Thoracic and Cardiac Surgery, Peter Bent Brigham Hospital, Harvard Medical School, Boston. Dr. Klovekorn was a research fellow in surgery at the time of the study. He is now with the Institute of Surgical Research, Munich, Germany.

Arch Surg. 1974;108(1):57-60. doi:10.1001/archsurg.1974.01350250049013

Plasma volumes, red blood cell volumes, large vessel hematocrit readings, and total blood volumes were measured before operation, immediately after operation, and four to six months later in 12 patients with coronary artery obstruction, disabling angina, and normal left ventricular function. There were significant plasma volume deficits in all patients before and six months after operation despite complete amelioration of angina and replenishment of the plasma volume immediately after surgery. The importance of recognizing possibly significant preoperative oligemia in patients undergoing coronary revascularization is emphasized.