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January 1974

Biochemical Aspects of Experimental Hepatic Allotransplantation

Author Affiliations

Sydney, Australia
From the departments of surgery (Drs. Halliday and Sheil) and anesthesia (Dr. Bookallil), University of Sydney, and departments of biochemistry (Dr. Hensley) and anesthesia (Dr. Wotherspoon), Royal Prince Alfred Hospital, Sydney, Australia.

Arch Surg. 1974;108(1):75-80. doi:10.1001/archsurg.1974.01350250065018

Fourteen porcine hepatic allografts were done using techniques designed for minimal damage to the allograft. Successful transplantation was achieved in ten; technical faults caused the four failures.

Hepatocellular damage reflected by elevated SGOT levels became evident during perfusion and developed slowly after revascularization. Similar changes in lactic dehydrogenase (LDH) levels were not found. Potassium efflux during cold perfusion appeared to be related not to damage, but to reversible changes in membrane potential and enzyme activity induced by hypothermia.

Interference with hepatic synthesis of plasma proteins and cholesterol was observed. The depression of cholesterol levels was short-lived in comparison with that of plasma protein.

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