A woman, who had lived in equatorial Africa, complained of pain in the right hypochondrium. Roentgenography revealed a calcified mass in the liver. The mass was removed surgically and was found to contain eggs of Fasciola gigantica, a fluke that rarely infests humans. The roentgenographic appearance of the lesion (its large size, uneven density, and polycyclic configuration) was distinct from that produced by other causes of hepatic calcification.