The coverage of large surface area skin wounds with autograft skin is limited by the amount of available viable donor-site skin. A small amount of donor-site epithelium can be expanded many times over by cultivation in tissue culture on sheets of skin allografts or xenografts. Experiments performed in rabbits indicate that such autograft-allografts or autograft-xenografts can be transplanted to large surface area wounds with essentially complete epithelial coverage of the wounds within two to three weeks, even with wound surface area coverage 50 times the surface area of donor-site skin.
Igel HJ, Freeman AE, Boeckman CR, Kleinfeld KL. A New Method for Covering Large Surface Area Wounds With Autografts: II. Surgical Application of Tissue Culture Expanded Rabbit-Skin Autografts. Arch Surg. 1974;108(5):724–729. doi:10.1001/archsurg.1974.01350290086015
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