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June 1974

The Ineffectiveness of Steroid Therapy in Treating Aspiration of Hydrochloric Acid

Author Affiliations

Gainesville, Fla
From the departments of anesthesiology (Drs. Chapman, Downs, and Modell) and pathology (Dr. Hood), University of Florida College of Medicine, J. Hillis Miller Health Center, and the Veterans Administration Hospital, Gainesville, Fla.

Arch Surg. 1974;108(6):858-861. doi:10.1001/archsurg.1974.01350300090021

Following aspiration of 0.1N hydrochloric acid with pH 1.0, 20 mongrel dogs were ventilated mechanically for four hours. Positive end-expiratory pressure of 10 cm H2O was added continuous positive-pressure ventilation (CPPV). In addition to CPPV, ten of the dogs received methylprednisolone (30 mg/kg body weight). The CPPV improved arterial oxygen tension, decreased venous admixture, increased arterial-venous oxygen content difference, and decreased systemic blood pressure. The addition of methyl-prednisolone did not significantly improve oxygenation, survival, or any other variable measured.