Following aspiration of 0.1N hydrochloric acid with pH 1.0, 20 mongrel dogs were ventilated mechanically for four hours. Positive end-expiratory pressure of 10 cm H2O was added continuous positive-pressure ventilation (CPPV). In addition to CPPV, ten of the dogs received methylprednisolone (30 mg/kg body weight). The CPPV improved arterial oxygen tension, decreased venous admixture, increased arterial-venous oxygen content difference, and decreased systemic blood pressure. The addition of methyl-prednisolone did not significantly improve oxygenation, survival, or any other variable measured.
Chapman RL, Downs JB, Modell JH, Hood CI. The Ineffectiveness of Steroid Therapy in Treating Aspiration of Hydrochloric Acid. Arch Surg. 1974;108(6):858–861. doi:10.1001/archsurg.1974.01350300090021
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