Stress ulcers are a frequent complication in patients with renal insufficiency. Rats were used to study the effect of renal insufficiency on restraint-induced stress ulcer formation. Acidotic, hyperkalemic renal insufficiency produced by the nephrotoxin uranyl nitrate and nonacidotic, normokalemic renal insufficiency produced by partial nephrectomy followed by internal contralateral nephrectomy enhance restraint-induced gastric erosions and ulcers. These studies demonstrate that both acute renal insufficiency with its concomitant acidosis and hyperkalemia and uremia enhance restraint-induced stress ulcer formation, possibly by impairing the normal reparative process of the gastric mucosa.
Fischer RP, Peter ET, Mullane JF. Experimental Stress Ulcers in Acidotic and Nonacidotic Renal Insufficiency. Arch Surg. 1974;109(3):409–411. doi:10.1001/archsurg.1974.01360030061016