Primary hepatic actinomycosis is extremely rare. The most effective treatment of actinomycosis is generally thought to be a combination of wide surgical excision and intensive, long-term penicillin therapy. In the case presented, prolonged penicillin therapy and removal of involved hepatic tissue in multiple-staged operative procedures were employed successfully. The patient died 27 months after the diagnosis of his disease, following prolonged alcoholic ingestion. He had no evidence of active actinomycosis when last examined ten weeks prior to his death.
Prioleau PG, Brochu FL. Penicillin and Épluchage Treatment of Hepatic Actinomycosis. Arch Surg. 1974;109(3):426–429. doi:10.1001/archsurg.1974.01360030078020