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October 1974

Diffuse Colonic Mucosal Hyperplasia: Morphology and Significance

Author Affiliations

From the departments of pathology (Dr. Prior) and surgery (Dr. Dunn), State University of New York, Upstate Medical Center, Syracuse, NY.

Arch Surg. 1974;109(4):575-577. doi:10.1001/archsurg.1974.01360040085022

An instance of diffuse colonic mucosal hyperplasia associated with a carcinoma of the rectum in a young man presented the opportunity to study several hundred hyperplastic foci and to contrast their structure with other recognized colonic lining abnormalities, ie, epithelial and lymphoid polyps. The histologic structure of these nodules is described in detail, with particular emphasis directed toward their association with lymphoid accumulations. This combination may have particular importance in view of current immunological concepts linking host defenses to lymphocytic activity. The controversial nature of the significance of mucosal hyperplasia is discussed and, while failing to document progression to cancer, we do believe these foci can be traced in their evolution into adenomatous polyps.