An instance of diffuse colonic mucosal hyperplasia associated with a carcinoma of the rectum in a young man presented the opportunity to study several hundred hyperplastic foci and to contrast their structure with other recognized colonic lining abnormalities, ie, epithelial and lymphoid polyps. The histologic structure of these nodules is described in detail, with particular emphasis directed toward their association with lymphoid accumulations. This combination may have particular importance in view of current immunological concepts linking host defenses to lymphocytic activity. The controversial nature of the significance of mucosal hyperplasia is discussed and, while failing to document progression to cancer, we do believe these foci can be traced in their evolution into adenomatous polyps.
Prior JT, Dunn E. Diffuse Colonic Mucosal HyperplasiaMorphology and Significance. Arch Surg. 1974;109(4):575–577. doi:10.1001/archsurg.1974.01360040085022
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