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December 1974

Canine Intrathoracic Hepatic Homograft: A Life-Supporting Procedure

Author Affiliations

From the Unité de Chirurgie Hepato-Biliaire et INSERM U-17, Hôpital Paul-Brousse, Villejuif, France.

Arch Surg. 1974;109(6):809-811. doi:10.1001/archsurg.1974.01360060075020

At the present time, no technique of heterotopic liver transplantation is capable of sustaining life in reproducible fashion unless portal blood is supplied to the graft. However, suppression of the portal blood risks compromising the function and eventual regeneration of the host liver, particularly if such a technique is to be used in the treatment of acute hepatic failure. The failure of heterotopic hepatic transplantation without portal blood may be due in part to unfavorable hemodynamic conditions. Livers grafted by a technique of intrathoracic homograft that aims to reproduce hemodynamic conditions close to the normal as regards inflow and venous drainage are capable of maintaining life in the hepatectomized dog.