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February 1975

Renal Trauma: Treatment by Angiographic Injection of Autologous Clot

Author Affiliations

From the Department of Surgery, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia. Dr. Silber is currently with the divisions of urology, University of California Medical Center and the Veterans Administration Hospital, San Francisco.

Arch Surg. 1975;110(2):206-207. doi:10.1001/archsurg.1975.01360080072012

The safety of treatment of renal hemorrhage from trauma with angiographic injection of autologous clot was investigated in rats by demonstrating the effect of various sizes of clot emboli on renal survival. A large amount of clot injected into the entire distal part of the renal arterial tree (equivalent to 20 cu cm in the human) was required to produce a 15% infarction. This large safety range is possibly due to the endogenous fibrinolytic capability of normal vascular endothelium.

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