Twenty-four patients (average age, 46 years) with 29 instances of lobular carcinoma in situ of the breast have been treated from 1952 to 1971 at the Henry Ford Hospital (incidence, 1%). Six patients had bilateral lesions, one synchronous and 5 metachronous.
The initial complaint in 23 of 24 patients was a mass in the breast. Diagnosis was based on permanent histologic section as mammography and frozen section analysis were inconclusive.
Treatment consisted of radical mastectomy in six, modified radical mastectomy in five, and simple mastectomy in 20. All lymph nodes recovered showed no metastatic disease. All patients are alive and well with no evidence of disease.
Based on our experience, we recommend a simple mastectomy for treatment of lobular carcinoma in situ with contralateral biopsy examination in those instances when clinical or roentgenographic evidence suggests a pathologic process.