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May 1975

The Solitary Pulmonary Nodule: Ten-Year Follow-Up of Veterans Administration-Armed Forces Cooperative Study

Author Affiliations

From the Veterans Administration Hospitals, Washington, DC (Dr. Higgins) and Chicago (Dr. Shields), and Follow-up Agency, National Research Council, Washington, DC (Mr. Keehn).

Arch Surg. 1975;110(5):570-575. doi:10.1001/archsurg.1975.01360110116019

Over a five-year span 1,134 patients with asymptomatic solitary pulmonary nodules were entered into a cooperative study. Of the 392 lesions found to be primary bronchogenic carcinoma, 67 patients were living and under observation ten years following operation. In the study, 32% of lesions were primary bronchogenic carcinoma, the incidence being 51% in patients above the age of 50 years. "Curative" resection was possible in 309 patients (78.9%) with a five-year observed survival of 38.5% and a ten-year observed survival of 20.1%. Factors that influenced long-term survival were size of lesion, age at operation, and interval between the last normal and the first abnormal x-ray film. Histologic cell type and extent of resection were not found to influence long-term survival.