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October 1975

Pseudomembranous Colitis After the Prophylactic Use of Clindamycin

Author Affiliations

From the Emergency Admitting Department, St. Louis City Hospital, St. Louis.

Arch Surg. 1975;110(10):1252. doi:10.1001/archsurg.1975.01360160090018

Clindamycin has become a popular antibiotic choice following a number of surgical procedures. Clindamycin is a semi-synthetic, wide-spectrum antibiotic derived from the parent compound, lincomycin, and was introduced because it had far fewer gastrointestinal side-effects than lincomycin.

A number of verified hospitalized cases of pseudomembranous colitis associated with oral clindamycin administration have been noted in the literature.1,2 Pseudomembranous colitis can be a very severe disorder associated with prolonged disabling diarrhea, abdominal pain and cramps, fever, and occasional hematochezia. Friable, edematous mucosa with unusual yellow-white plaques can be seen on sigmoidoscopic examination.

REPORT OF A CASE  Recently we admitted a 40-year-old nurse to the medical service who had undergone an elective cosmetic rhinoplasty and was post-operatively placed on a regimen of 150 mg clindamycin administered orally four times a day to prevent any potential infection from a nasal pack. During the immediate postoperative period the patient developed a very vague