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January 1976

Arteriovenous Fistulas Constructed With Modified Human Umbilical Cord Vein Graft

Author Affiliations

From the Laboratory for Experimental Medicine and Surgery in Primates, New York University Medical Center, New York, and the Division of Biologic Graft Research, Meadox Medicals, Inc, Oakland, NJ.

Arch Surg. 1976;111(1):60-62. doi:10.1001/archsurg.1976.01360190062010

• Arteriovenous (AV) shunts were created using modified umbilical veins in baboons. The shunts consisted of veins removed from human umbilical cords tanned by either dialdehyde starch or glutaraldehyde 2% and surrounded with a polyester fiber mesh. Twelve fistulas were constructed employing the femoral or axillobrachial vessels. Six of the seven straight axillobrachial shunts remained patent for up to four months during the period of study. One of two loop fistulas and three femoral AV fistulas thrombosed because of kinking. There were no infections, mural disruptions, or aneurysm formations. Angiogram results and histologic studies confirmed the maintenance of graft function, morphologic appearance, and tolerance to repetitive punctures.

(Arch Surg 111:60-62, 1976)