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May 1976

Hazards of Heparin Therapy-Reply

Arch Surg. 1976;111(5):615. doi:10.1001/archsurg.1976.01360230114033

In Reply.—The argument regarding the efficacy of continuous vs intermittent intravenous heparin therapy has been continuing for years. A recent controlled prospective trial comparing the two modalities demonstrated that although there were fewer bleeding complications in the group receiving continuous heparin sodium infusion, there were no significant differences in the doses of heparin used daily between those who bled and those who did not bleed in any of the groups.1 Furthermore, the frequency of bleeding was the same in those who had determinations of partial thromboplastin time as in those who had "no laboratory control" of the heparin dosage when intermittent schedule was used.

We wish to bring attention to the dangers of the use of heparin soon after major arterial surgery, and propose that it disrupts the dynamic balance between resorption of old thrombus and replacement with new clot until the suture line is sealed with new

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