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November 1976

Prolonged Pulseless Perfusion in Unanesthetized Calves

Author Affiliations

From the Department of Surgery, University of California at San Diego School of Medicine, La Jolla.

Arch Surg. 1976;111(11):1225-1230. doi:10.1001/archsurg.1976.01360290059008

• Nonpulsatile left ventricular (LV) bypass was achieved in nine alert, active calves for periods of up to two weeks using a centrifugal blood pump. Data were compared to prebypass control values and to results obtained from seven calves that underwent nonthoracotomy, retrograde LV cannulation, and pulsatile bypass for up to 35 days.

Nonpulsatile flow produced an increase in heart rate of 20% (P <.05) and an increase in aortic pressure of 10% (P <.05). Cardiac output and systemic vascular resistance were similar in both groups for three days; thereafter, vascular resistance decreased as cardiac output progressively increased. Serum renin, lactate, and pyruvate values remained normal; creatinine clearances were not significantly different than control values, and there were no significant changes in body weight. These data indicate no untoward effects as a result of prolonged pulseless perfusion.

(Arch Surg 111:1225-1230, 1976)