[Skip to Navigation]
Sign In
May 1977

Portacaval Diversion for Severe Hypercholesterolemia: Report of a Case With Measurements of Glucose Tolerance, Insulin, and Glucagon Levels

Author Affiliations

From the Departments of Biophysics and Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond (Dr Weglicki), and the Joslin Research Laboratory (Drs Ganda and Soeldner) and the Departments of Surgery (Drs Cohn and Couch) and Medicine (Dr Murawski), Peter Bent Brigham Hospital and Harvard Medical School, Boston.

Arch Surg. 1977;112(5):634-636. doi:10.1001/archsurg.1977.01370050094016

• An end-to-side portacaval shunt was performed in a patient with severe coronary arteriosclerosis and type Ila hypercholesterolemia. By one year postoperatively there was a decrease of serum cholesterol concentration of more than 40%. No adverse side effects were noted. Intravenous and oral glucose tolerance tests were performed and were within normal range preoperatively and postoperatively. However, preoperatively, during the oral test, the serum insulin levels exceeded the normal range. In addition, glucagon levels revealed less tendency to suppression during the preoperative oral tests. Psychological testing revealed no abnormalities, and serum ammonia levels were only slightly elevated.

(Arch Surg 112:634-636, 1977)

Add or change institution