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January 1978

The Lipid Hypothesis: Pathophysiological Basis

Author Affiliations

From the Department of Lipid Metabolism and Atherosclerosis Research, Clinical Research Institute of Montreal, the Section of Vascular Medicine, Hôtel-Dieu Hospital of Montreal, and the Faculty of Medicine, University of Montreal.

Arch Surg. 1978;113(1):28-34. doi:10.1001/archsurg.1978.01370130030005

• A detailed analysis of the multifactorial pathogenesis of atherosclerosis, including endothelial injury, proliferation of intimal smooth muscle cells, the role of the platelet, the role of cholesterol as raw material and irritant, the influence of inflammation, and the participation of lysosomal components, is presented.

(Arch Surg 113:28-34, 1978)