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January 1979

Postmortem Findings in Three Patients Treated With Intravenous Fat Emulsions

Author Affiliations

From the Department of Surgery, Horsens Sygehus (Dr Hessov), the University Institute of Pathology, Århus Amtssygehus (Dr Melsen), and the Institute of Pathology, Vejle Sygehus (Dr Haug), Århus, Denmark.

Arch Surg. 1979;114(1):66-68. doi:10.1001/archsurg.1979.01370250068014

• Three patients died of intercurrent illness in relation to intravenous nutrition with fat emulsions (20% Intralipid). In two cases, postmortem findings showed milky white, shiny, clotted lumps in the heart, with a fatty acid composition resembling that of fat emulsions. In vitro investigations make it likely that fibrin deposits in hyperlipemic plasma composed the lumps. In two cases, 30- to 50-μ Sudan-positive accumulations were found in the small vessels of the lungs, the cerebrum, and the kidneys.

(Arch Surg 114:66-68, 1979)