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August 1979

Factors Determining Peripheral Vein Tolerance to Amino Acid Infusions

Author Affiliations

From the Departments of Surgery (Dr Gazitua) and Intravenous Therapy (Ms Wilson), and the Nutrition Support Service (Drs Bistrian and Black-burn), New England Deaconess Hospital, Boston; and the Departments of Surgery (Drs Gazitua and Blackburn) and Medicine (Dr Bistrian), Harvard Medical School, Cambridge, Mass.

Arch Surg. 1979;114(8):897-900. doi:10.1001/archsurg.1979.01370320029005

• The tolerance of peripheral veins to intravenous infusions was evaluated. Of 83 infusions studied, 67 contained amino acids. Phlebitis occurred more commonly with the use of solutions that contained the amino acids. The important factors in the production of phlebitis by amino acid solutions were osmolarity, and the amount of potassium infused per day. Phlebitis was universal when osmolarity exceeded 600 mOsm. Other factors that promoted phlebitis were the presence of antibiotics and the size of the vein.

(Arch Surg 114:897-900, 1979)

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