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To the Editor.—I wish to add another case of solitary ganglioneuroma of the colon to that reported by Bibro et al (Archives 115:75-77, 1980). The patient was a 37-year-old man noted to have an asymptomatic 1.5-cm in diameter sessile polypoid lesion of the colon with normal-appearing overlying mucosa 13 cm from the anus on routine examination on March 14, 1978. This lesion was excised with cautery snare on March 31, 1978. The microscopic appearance was decribed as follows: The lesion consisted of an intramural mass composed of interlacing fascicles of closely packed bundles of Schwann cells and neurites in a fibrous stroma rich in mucopolysaccharide. Some of the neurites were myelinated. Groups of typical adult ganglion cells were present, some of which contained perikaryon Nissl bodies. Some had prominent nucleoli and occasional binucleated forms were seen. The vessels showed thick hyaline cuffing; occasional lymphocytes and eosinophils were present. Thick