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July 1980

Common Bile Duct Pressure During Enflurane Anesthesia: Effects of Morphine and Subsequent Naloxone

Author Affiliations

From the Naval Regional Medical Center, Jacksonville, Fla. Dr Dedrick is now with the Harvard Medical School, Boston; Dr Tanner is now with Chippenham Anesthesia Associates, Inc, Richmond, Va; Dr Bushkin is now with the University of Florida College of Medicine, Gainesville.

Arch Surg. 1980;115(7):820-822. doi:10.1001/archsurg.1980.01380070014003

• In ten otherwise healthy patients undergoing cholecystectomy and cholangiography, morphine sulfate, in a dose of 2.5 mg/70 kg body weight, significantly elevated common bile duct pressure, as measured by water manometry, two and five minutes after intravenous injection. There was no added effect from an additional 7.5 mg/70 kg, measured two and five minutes after injection. Naloxone hydrochloride, in a dose of 1.0 mg/70 kg body weight, quickly reversed the increase in pressure caused by the morphine. Radiographic contrast material passed into the duodenum in every patient after administration of naloxone.

(Arch Surg 115:820-822, 1980)

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