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September 1980

Arteriovenous Carcinoembryonic Antigen Gradient: Determination by Selective Angiography for Localization of Metastatic Colorectal Cancer

Author Affiliations

From the Departments of Developmental Therapeutics (Drs Patt and Mavligit) and Diagnostic Radiology (Dr Chuang), University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston; and the Department of Surgery, University of Missouri Medical School (Dr Faltely), Kansas City, Mo.

Arch Surg. 1980;115(9):1122-1124. doi:10.1001/archsurg.1980.01380090088021

• Two colorectal carcinoma patients with elevated serum carcinoembryonic antigen (CEA) levels are discussed. In the first patient, metastatic disease in the left adrenal gland was diagnosed by computerized tomography scanning. A CEA concentration gradient between the left adrenal artery and the left adrenal vein was detected by selective sampling of the appropriate vessels. After adrenalectomy, the serum CEA level returned to normal. In the second patient, a CEA gradient between the hepatic artery and the left hepatic vein helped localize metastatic disease in the left lobe of the liver, before it became evident by any other means. We conclude that subselective angiography and sampling of serum for CEA levels could serve as an auxiliary method of detecting obscure metastatic colorectal carcinoma in patients with elevated levels of the antigen.

(Arch Surg 115:1122-1124, 1980)

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