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December 1980

Early Proliferative Activity: Its Occurrence in the Crypts of Small Bowel and Colon After Partial Small-Bowel Resection

Author Affiliations

From the Departments of Surgery (Dr Tilson) and Medicine (Dr Livstone), Yale University School of Medicine, New Haven, Conn.

Arch Surg. 1980;115(12):1481-1485. doi:10.1001/archsurg.1980.01380120049012

• Crypt population kinetics in both small bowel and colon were determined in the early postoperative period in the rat after either sham resection or resection of 50% of the midportion of the small bowel. A proliferative response was evident in the colon within 24 hours. This response of the labeling index was statistically significant in the left colon by comparison with the sham-resected animals, whereas in the right colon it was significant by comparison not only with the sham-resected but also with the intact animals. A proliferative response was documented in the remnants of the small bowel on the third postoperative day by comparison with those of the sham-resected animals. These findings indicate that adaptive hyperplasia begins very promptly in the intestinal remnants after partial resection.

(Arch Surg 115:1481-1485, 1980)

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