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April 1981

Recurrence of Neuroblastoma Following Prolonged Remission

Author Affiliations

From the Department of Surgery, Section of Surgical Oncology (Drs Sutherland and Krementz); the Department of Pathology (Dr Harkin); and the Department of Obstetrics and Gynecology (Dr Culotta), Tulane University School of Medicine, New Orleans.

Arch Surg. 1981;116(4):474-475. doi:10.1001/archsurg.1981.01380160084018

• A 6-year-old girl with unresectable and metastatic neuroblastoma had a complete remission with irradiation to the primary tumor and systemic administration of cyclophosphamide. The patient was disease-free for 16 years but had an explosive recurrence of tumor six weeks after a hysterectomy. Although no clear cause-and-effect relationship exists between the surgery and the recurrence, this case illustrates that a recurrence is possible after a long disease-free interval. Diagnostic and therapeutic procedures in such patients should be undertaken with caution.

(Arch Surg 1981;116:474-475)

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