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April 1981

Pseudoxanthoma Elasticum and Polyposis Coli: A Novel Co-mutation

Author Affiliations

From the Department of Surgery, Stanford University Medical Center, Stanford, Calif.

Arch Surg. 1981;116(4):476-477. doi:10.1001/archsurg.1981.01380160086019

• Pseudoxanthoma elasticum and polyposis coli are inherited conditions not, to our knowledge, previously reported to coexist. The spontaneous appearance of both conditions in a 62-year-old woman may represent a novel mutation. The defective cell in both pseudoxanthoma and some of the extracolonic manifestations of Gardner's syndrome is the fibroblast; therefore, this case may represent a unique variation of Gardner's syndrome.

(Arch Surg 1981;116:476-477)