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July 1981

Mucoid Colonic Carcinoma as an Autosomal-Dominant Inherited Syndrome

Author Affiliations

From the Departments of Surgery, St Joseph's Hospital and Medical Center and Barnert Memorial Hospital, Paterson, NJ.

Arch Surg. 1981;116(7):901-905. doi:10.1001/archsurg.1981.01380190035008

• An autosomal-dominant mucoid colonic carcinoma syndrome is described. Seventeen members of one family over three generations have experienced cancers, including 14 with adenocarcinoma of the colon. The defective autosomal locus is pleiotropic, producing adenocarcinoma of the endometrium, atypical endometrial hyperplasia, uterine leiomyosarcoma, and bladder transitional and renal cell carcinoma in addition to the mucoid variant of colon carcinoma.

(Arch Surg 1981;116:901-905)

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