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July 1981

Sequence of Regional Chemotherapy and Surgery: Management of Colorectal Adenocarcinoma Confined to the Liver

Author Affiliations

From the Departments of Developmental Therapeutics (Drs Tilchen, Patt, and Mavligit), Surgery (Dr McBride), and Diagnostic Radiology (Drs Wallace and Chuang), University of Texas System Cancer Center, M.D. Anderson Hospital, Houston.

Arch Surg. 1981;116(7):959-960. doi:10.1001/archsurg.1981.01380190085020

• Four patients with clinically nonresectable unilobar hepatic metastases from colorectal cancer were treated with a sequentially combined approach of intrahepatic arterial chemotherapy followed by surgery. Partial regression (≥ 50%) induced by chemotherapy and associated with a decline in plasma carcinoembryonic antigen level was followed successfully by a complete hepatic tumor resection in three out of four patients. All three patients continue to be free of disease from 13+ to 21+ months. This combined approach may improve the salvage rate of patients with regionally confined hepatic metastases.

(Arch Surg 1981;116:959-960)

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