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October 1981

Pancreatic Polypeptide: A Review

Author Affiliations

From the Department of Surgery, The University of Texas Medical Branch, Galveston (Drs Lonovics, Watson, Rayford, and Thompson and Mr Devitt); Szeged University Medical School, Hungary (Dr Lonovics); and University of Bristol, England (Mr Devitt). Mr Devitt is now with Liverpool Royal Hospital, England, and Dr Rayford is now with The University of Arkansas School of Medicine, Little Rock.

Arch Surg. 1981;116(10):1256-1264. doi:10.1001/archsurg.1981.01380220010002

• Pancreatic polypeptide (PP), a 36-amino acid peptide, may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal, primarily protein, occurs in a biphasic manner. The first rapid release occurs as a result of vagal stimulation; the second, more prolonged rise (the so-called intestinal phase) occurs in response to hormonal stimulation, predominantly cholecystokinin. Plasma PP levels increase with age; PP levels are elevated above those of age-controlled normal subjects in diabetic patients and in some patients with pancreatic amine precursor uptake decarboxylase tumors. The value of plasma PP as a possible marker for pancreatic tumors is as yet unsettled but may be a valuable tool.

(Arch Surg 1981;116:1256-1264)

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