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February 1982

Postoperative Peritonitis Caused by Saccharomyces cerevisiae

Author Affiliations


Arch Surg. 1982;117(2):248-249. doi:10.1001/archsurg.1982.01380260114019

To the Editor.—Saccharomyces cerevisiae, baker's yeast, is an uncommon cause of infection in humans. Although it has been reported as a cause of fungemia in a patient with a prosthetic heart valve,1 as well as pulmonary infections,2 it has never, to our knowledge, been reported to produce abdominal sepsis. We report a case of postoperative peritonitis caused by S cerevisiae that was successfully treated with the new antifungal agent, ketoconazole.

Report of a Case.—A 66-year-old man had signs of extrahepatic biliary obstruction, including painless jaundice and an enlarged gallbladder. A diagnosis of pancreatic cancer was made, and the patient underwent an exploratory laparotomy. A large malignant neoplasm was found in the head of the pancreas, and a total pancreatectomy was carried out with choledochojejunostomy and gastrojejunostomy. The postoperative course was complicated by a prolonged ileus, low-grade fever, and a persistent leukocyte count in the range