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October 1982

Prevention of Postoperative Peritoneal Adhesions: Efficacy of Povidone

Author Affiliations

From the Department of Surgery, Section of Pediatric Surgery and Price Institute of Surgical Research (Drs Janik, Nagaraj, and Groff), University of Louisville School of Medicine; and the Section of Pediatric General and Thoracic Surgery (Dr Nagaraj), Department of Surgery (Dr Groff), Kosair-Children's Hospital, Louisville. Dr Janik is now at Denver Children's Hospital.

Arch Surg. 1982;117(10):1321-1324. doi:10.1001/archsurg.1982.01380340047011

• The appearance and severity of peritoneal adhesions after simple laparotomy and after adhesiolysis were studied in a rabbit model. Adhesions were induced by direct abrasion with latex glove and dry gauze; control rabbits had abrasion only. Study groups had abrasion and treatment with 10% or 25% povidone. Results showed a significant reduction in the number of adhesions and in the severity of adhesions after treatment with povidone. This study supports the further investigation of the efficacy of povidone in preventing postoperative peritoneal adhesions.

(Arch Surg 1982;117:1321-1324)

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