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October 1982

Development of a New Vascular Prosthetic: Lessons Learned

Author Affiliations

From the Department of Surgery, University of Colorado Health Sciences Center, Denver.

Arch Surg. 1982;117(10):1367-1370. doi:10.1001/archsurg.1982.01380340081019

• In 1972, polytetrafluoroethylene (PTFE) (Gore Tex) wire insulation was first implanted into arteries and veins of dogs at the University of Colorado Health Sciences Center in Denver. Subsequent modifications including fibrillar arrangement, wall thickness, and pore size led to the development of a vascular prosthesis with tissue ingrowth, viable neointima, and encouraging patency rates. Tissue culture, surface charge, and platelet studies have all demonstrated the optimal biologic qualities of PTFE grafts. Replacement of one human portal vein by a PTFE graft for invasive carcinoma of the pancreas was strikingly successful. Only unexplained intimal hyperplasia at the arterial anastomotic margins discouraged us from extensive early clinical trials.

(Arch Surg 1982;117:1367-1370)