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February 1983

Third-Generation Cephalosporins for Polymicrobial Surgical Sepsis

Author Affiliations

From the Department of Surgery, Emory University School of Medicine, Atlanta.

Arch Surg. 1983;118(2):193-200. doi:10.1001/archsurg.1983.01390020047009

• During 31 months of study, 808 patients with polymicrobial surgical infection were randomized for antibiotic therapy between a third-generation cephalosporin (moxalactam disodium [149], cefotaxime sodium [125], and cefoperazone sodium [141]) and the combination of gentamicin sulfate plus clindamycin (393). Results based on antibiotic therapy included the following: cure in 83% given cephalosporin, 73% with antibiotic combination; control but recurrent sepsis in 7% and 15%; and failure in 4% and 8%, respectively. Such data support the tenet that third-generation cephalosporins are at least equal, if not superior, to the combination of gentamicin plus clindamycin for treatment of polymicrobial surgical sepsis.

(Arch Surg 1983;118:193-200)