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February 1983

Penetration of Eight β-Lactam Antibiotics Into the Peritoneal Fluid: A Pharmacokinetic Investigation

Arch Surg. 1983;118(2):205-213. doi:10.1001/archsurg.1983.01390020055010

• Serial serum and peritoneal fluid samples were taken after intravenous injection of cefuroxime sodium, cefoxitin sodium, cefotaxime sodium, cefoperazone sodium, ceftazidime, moxalactam disodium, mezlocillin sodium, and piperacillin sodium. Time-concentration curves were obtained for both pharmacokinetic compartments. The geometric mean of peritoneal fluid concentrations from eight to ten patients was used to define the time-concentration curve for each substance. Serum pharmacokinetic values were calculated using an open two-compartment model. The concentrations (Cps) were calculated from peritoneal fluid concentrations by quadratic interpolation. The time for which one fourth of the Cp (Cp¼) is maintained within the peritoneal cavity varied according to the substance and can be used to estimate dosage intervals. The Cp¼ was compared with the minimal inhibitory concentrations for 1,344 pathogens encountered in 415 intra-abdominal infections from 31 studies.

(Arch Surg 1983;118:205-213)