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April 1983

Intraperitoneal Splenic Autotransplantation: Protection Afforded in a Naturally Occurring Epidemic of Murine Mycoplasmosis

Author Affiliations

From the Surgical Service, Audie L. Murphy Memorial Veterans Hospital (Dr Levine), and the Department of Surgery, University of Texas Health Science Center (Drs Livingston and Sirinek), San Antonio.

Arch Surg. 1983;118(4):458-461. doi:10.1001/archsurg.1983.01390040068014

• Intraperitoneal splenic autotransplantation is now a clinical reality. However, doubts remain as to complications that might develop when splenic tissue is placed in this site. We assessed the ability of an extraperitoneal (subcutaneous) site of autotransplantation to provide protection similar to that previously demonstrated by intraperitoneal splenic reimplantation. These effects were studied during a naturally occurring epidemic of murine respiratory mycoplasmosis. Intraperitoneal splenic transplants but not subcutaneous implants improved chances for survival during this infectious epidemic. The results suggest that a subcutaneous site for splenic autotransplantation is not clinically applicable.

(Arch Surg 1983;118:458-461)