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January 1984

Effect of Abdominal Operations on Survival After Septic Challenge in Normal Rats

Author Affiliations

From the Department of Surgery (Dr Selivanov), and the Trauma and Hyperalimentation Services, San Francisco General Hospital (Dr Sheldon); and the Department of Surgery, University of San Francisco (Dr Sheldon).

Arch Surg. 1984;119(1):71-74. doi:10.1001/archsurg.1984.01390130055010

• We evaluated the effect of 60% small-bowel enterectomy that removed 75% of Peyer's patches, and the effects of lesser abdominal operations, on the survival of rats following inducement of peritonitis. We divided 286 female Fischer rats weighing 140 to 200 g into four experimental and two control groups. Following enterectomy, rats recovered for ten to 14 days before peritonitis was induced by intraperitoneal injection of 0.7 mL/100 g of body weight of a solution of 4% hemoglobin and Escherichia coli (109/mL). At 48 hours after enterectomy, the survival rate was better than that in rats not operated on or anesthetized. Survival rates for rats having lesser intra-abdominal operations were significantly greater after peritonitis than the rates for controls, but were similar to rates for rats having enterectomies. Our results suggest that intra-abdominal operation of minimal or large magnitude is associated with improved survival from hemoglobin—E coli adjuvant peritonitis.

(Arch Surg 1984;119:71-74)