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May 1984

Primary Aldosteronism: Clinical Management

Author Affiliations

From the Departments of Surgery (Drs Grant and van Heerden) and Internal Medicine (Dr Carpenter), Mayo Clinic and Mayo Foundation, Rochester, Minn; and the Department of Surgery, Karolinska Hospital, Stockholm (Dr Hamberger).

Arch Surg. 1984;119(5):585-590. doi:10.1001/archsurg.1984.01390170081016

• We retrospectively reviewed the clinical features, methods of diagnosis and localization, and results of treatment in 105 patients with primary aldosteronism seen between 1969 and 1981. Coincident with the use of computed tomography (CT), 131I-6-β-iodomethyl norcholesterol scans (NP-59), and postural response studies, the study group was temporally divided into pre-1976 and post-1976 groups, and subdivided into groups with aldosterone-producing adenoma (APA) and idiopathic hyperaldosteronism (IHA) due to bilateral adrenal hyperplasia. Our results indicate that aldosterone postural response studies and CT differentiate and localize APA and IHA reliably. Adrenalectomy is a safe and effective treatment for APA, whereas medical treatment alone is preferable for IHA.

(Arch Surg 1984;119:585-590)

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