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December 1984

Evaluation of Naloxone for Therapy of Escherichia coli Shock: Species Differences

Author Affiliations

From the Veterans Administration Medical Center (Drs Hinshaw, Flournoy, and Archer and Ms Beller) and Departments of Physiology and Biophysics (Dr Hinshaw), Surgery (Dr Hinshaw), and Pathology (Drs Flournoy, Passey, and Archer), University of Oklahoma Health Sciences Center, Oklahoma City, and the CNS Disease Research Division of The Upjohn Co (Dr Lahti), Kalamazoo, Mich.

Arch Surg. 1984;119(12):1410-1418. doi:10.1001/archsurg.1984.01390240048009

• Dogs and baboons were infused intravenously (IV) with Escherichia coli and treated with the opiate antagonist, naloxone hydrochloride, and the antibiotic, gentamicin sulfate, to determine the therapeutic efficacy of naloxone. Naloxone hydrochloride (2 mg/kg) was injected IV when one fourth of the E coli had been Infused and then infused at 2 mg/kg/hr (six hours for dogs and 12 hours for baboons). Four of five naloxone-treated dogs survived permanently (greater than seven days), while all dogs that were given only E coli died. Arterial BP, blood glucose levels, Pco2, and Po2 were supported at higher levels and lesions of the gastrointestinal tract were prevented In naloxone-treated dogs. A steady decline in blood glucose levels after an initial hyperglycemia was observed in naloxone-treated baboons, indications of peripheral vasoconstriction were noted, and all baboons died within 42 hours.

(Arch Surg 1984;119:1410-1418)

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