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January 1985

The Application of Antibiotic Bonding to the Treatment of Established Vascular Prosthetic Infection

Author Affiliations

From the Department of Surgery, Rutgers Medical School, Academic Health Science Center, New Brunswick, NJ.

Arch Surg. 1985;120(1):71-75. doi:10.1001/archsurg.1985.01390250063010

• We used surfactant-mediated antibiotic bonding to treat established vascular prosthetic infections in an animal model. The infrarenal aorta of dogs was replaced with a polytef (PTFE) graft locally contaminated with Staphylococcus aureus. Infected grafts were then replaced with control polytef or polytef bonded with benzylkonium chloride and penicillin G tagged with radioactive carbon, or polytef bonded with tridodecylmethylammonium chloride and penicillin G tagged with radioactive carbon. Both types of antibiotic-bonded grafts had significantly fewer infections than control grafts did. The labeled penicillin G remained bound to both groups of antibiotic-bonded grafts for at least three weeks. In a second group of studies, surfactant-treated polytef adsorbed parenterally administered labeled penicillin G in highly significant concentrations compared with control grafts. These studies suggest the possibility that human vascular prosthetic infection may be treated with an antibiotic-bonded graft.

(Arch Surg 1985;120:71-75)

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