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March 1985

Candida Sepsis: Implications of Polymicrobial Blood-Borne Infection

Author Affiliations

From the Departments of Surgery, Veterans Administration Medical Centers, Louisville (Drs Dyess and Garrison) and Cleveland (Dr Fry); University of Louisville (Drs Dyess and Garrison); and Case Western Reserve University, Cleveland (Dr Fry).

Arch Surg. 1985;120(3):345-348. doi:10.1001/archsurg.1985.01390270083014

• Eighty-three patients with 117 episodes of candidemia were reviewed to examine the clinically significant variables and the results of treatment for this problem. Mortality was 52%. Patients who had bacteremia either synchronously or metachronously in association with Candida species had poorer survival rates. Staphylococcal and enterococcal species were the most frequently associated bacteria. Patients with Candida parapsilosis had better survival rates than patients with other species. Portals of entry for fungemia were catheters, wounds, the urinary tract, and the peritoneal cavity, but were undefined in 54% of patients. Antifungal chemotherapy could not be identified as affecting the outcome in these patients. It is suggested that candidemia in most patients represents a failure of host defense, and that septicemia of either bacteria or fungi may arise from the gastrointestinal tract in critically ill, immunocompromised patients.

(Arch Surg 1985;120:345-348)

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